Lexicon

Merle coloured dogs show a pattern of darker and lighter patches which appears random. The eyes may be lighter or blue in colour.

The colour is caused by the M allele of the M locus. Homozygous animals (M/M) have severe health problems such as deafness, blindness and organ problems.

Genetic Test: available in Shop

Muscle Integrity Myopathy (formerly known as "PSSM2") is form of Exertional Myopathy (link in those words), in which the structure and/or function of the muscle is disrupted.  It is caused by hereditary predisposition and various environmental factors (age, feeding, husbandry). Typical symptoms can include unexplained lameness, muscle stiffness, difficulties with gait changes/coordination, reluctance to move, muscle atrophy and/or difficulty building muscle. Almost any breed of horse can be affected.
Six genetic variants that can disrupt muscle structure and/or function have been identified in horses. These predispose a horse to developing symptoms of exertional myopathy.

Muscle Integrity Myopathy Test: available in Shop

Mushroom is a coat colour unique to the Shetland Pony, where phaeomelanin (chestnut colour) is lightened to a light sepia shade. Mushroom can also slightly affect the coat colour of ponies with bay base colour.

The colour is inherited autosomal recessively. Animals with one copy of the mutation (N/mu) show no dilution. Only animals with two copies of the mutation (mu/mu) show the Mushroom dilution.

Genetic Test: available in Shop

MYH1 Myopathy is an autoimmune disease where a horse can have an immune reaction against its own muscle cells.  There are two clinical presentations of MYHM: 

Immune-mediated myopathy (IMM) and non-exertional rhabdomyolysis.

The tested genetic mutation is a risk factor for these conditions. The disease is incomplete autosomal dominant and occurs in Quarter Horses and related breeds.

Naked Foal Syndrome (NFS) refers to lethal hairlessness in Akhal-Teke horses. Affected foals have almost no hair and usually die shortly after birth. The disease is inherited in an autosomal recessively.

Genetic Test: available in Shop

With narcolepsy (canarc-1), dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the dachshund. The inheritance is autosomal recessive.

Genetic Test: available in Shop

With narcolepsy (canarc-1) dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the Doberman. The inheritance is autosomal recessive.

Genetic Test: available in Shop

Also in the Doberman 1 package

With narcolepsy (canarc-1) dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the Labrador Retriever. The inheritance is autosomal recessive.

Genetic Test: available in Shop

Also in the Labrador Retriever B package (DRC P3)

Neuronal ceroid lipofuscinosis 1 (NCL1) is a metabolism-induced neurodegenerative disease in Dachshunds caused by an alteration of a single base pair in exon 8 of the PPT1 gene. In this disease, a waste product of cell metabolism (ceroid lipofuscin, CL), is stored in the cells and is not metabolised further. CL accumulates in the nerve cells of the retina and brain. Affected animals therefore show symptoms such as visual disorders, balance disorders and later completely disoriented behaviour and physical degeneration.

The inheritance is autosomal recessive.

Genetic Test: available in Shop

Also in the Hereditary diseases Dachshund 1 package

Neuronal ceroid lipofuscinosis 2 (NCL2) is a metabolism-induced neurodegenerative disease caused by a deletion of a single base pair in exon 4 of the TPP1 gene. In this disease, the waste product of cell metabolism, ceroid lipofuscin, is stored in the cells and is not metabolised further. This accumulates in the nerve cells of the retina and brain. Affected animals therefore show symptoms such as visual disorders, balance disorders and later completely disoriented behaviour and physical degeneration.

The disease occurs in Dachshunds. The inheritance is autosomal recessive.

Genetic Test: available in Shop

Also in the Hereditary diseases Dachshund 1 package