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Lexicon

Ichthyosis (PNPLA1-related Golden Retriever)

Ichthyosis (PNPLA1-related) is a cornification disorder of the skin. This leads to defects in the development of the outer layer of the epidermis. Affected animals show increased scaling (desquamation) and detachment of the outer skin layer.

The hereditary disease occurs in the Golden Retriever. The inheritance is autosomal recessive.

Synonym: ICT-A

 

Genetic Test: available in Shop

Also in the Golden Retriever A package (DRC P2)

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Immune-Mediated Myositis (IMM Horse)

Immune-mediated myositis (IMM) is an immune reaction against the horse's own muscle cells, resulting in muscle loss, often triggered by infections or vaccinations.

The disease occurs in the Quarter Horse and related breeds. The inheritance is incomplete autosomal dominant.

Synonym: MYH1 myopathy

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Incontinentia Pigmenti (IP Horse)

Coat pattern with negative effects on skin, coat, teeth and eyes

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Intervertebral Disc Disease (IVDD Dog)

With intervertebral disc disease (IVDD), degeneration and/or calcification of the intervertebral discs occurs, causing the gelatinous core to press on the spinal cord. This causes pain and paralysis and can damage the nerves. Two types are distinguished: IVDD type 1 and IVDD type 2.

A risk factor for the development of IVDD type 1 has been discovered, an insertion of an FGF4 retrogene at a specific site on chromosome 12. A genetic test is available for this.

The disease occurs predominantly, but not exclusively, in certain short-legged dog breeds. The inheritance is incomplete autosomal dominant.

 

Genetic Test: available in Shop

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