Lexicon

Glycogen Storage Disease IV (GSD IV) causes energy deficiency in muscles and organs due to a disorder in glycogen metabolism. The disease occurs in the Quarter Horse and related breeds.

Synonym: Glycogen Branching Enzyme Deficiency (GBED)

Glycogen storage disease IIIa (GSD 3a) is a metabolic disease. In type 3a, glycogen cannot be metabolised due to an enzyme defect. This leads to glycogen accumulation in the liver and muscles, which are impaired in their function. The symptoms of lethargy, exercise intolerance and collapse occur at the age of 14 months.

The disease occurs in the Curly Coated Retriever. The inheritance is autosomal recessive.

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Golden Retriever Muscle Dystrophy (GRMD) is a degenerative muscle disease in which muscle fibre degeneration and necrosis occur due to a malformation of the dystrophin protein. Affected dogs suffer from muscle wasting, weakness and feeding difficulties. The poor quality of life often leads to euthanasia.

The disease occurs in Golden Retrievers and is inherited in an X-linked recessive manner.

Synonym: X-linked muscular dystrophy, Duchenne muscular dystrophy, Dystrophin-deficient muscular dystrophy

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Also in the Golden Retriever B package (DRC P4)

Due to the Grey mutation, normally coloured foals first turn grey and later white. They slowly "lose" their colour, as pigment-producing cells gradually stop to produce pigment and the hairs that grow back have less and less colour pigments and eventually none at all. Transitions patterns such as "dapple grey" and "flea-bitten" etc. develop.

The responsible gene (STX17) is involved in cancer pathways. The duplication that causes the grey colour also predisposes grey horses to developing melanoma.

The dog has a light face mask with so-called "widow's peak". This colour pattern is caused by the Eg allele of the extension locus.

See: Extension (Coat colour E-Locus Dog)

The Haflinger is one of the best-known small horse breeds in the world and originally comes from the Alpine regions of South Tyrol and Austria. It combines robustness, versatility and a friendly nature - characteristics that make it very popular with leisure riders as well as in sport and therapy.

Hair length is a trait in many dog breeds, which is important in the selection of intended matings. There is usually a short coat type and a long coat type.

Which genetic type the dog has, i.e. which coat length it develops, can be determined by a genetic test (FGF5 gene).

This coat structure occurs in many different breeds.

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Hairlessness (ectodermal dysplasia) results in bald (hairless) patches all over the body. The trait occurs in a few breeds, e.g. Chinese Crested Dog and Mexican Naked Dog. It is homozygous lethal. Dogs with two copies of the mutated gene die before birth.

Harlequin dogs show black patches on a white base coat. It is a modified version of the Merle colouration. This means that all dogs showing the Harlequin pattern in the phenotype also have one copy of the Merle mutation. Dogs without the mutation for Merle (m/m), can be carriers for Harlequin.

The colour is caused by the H allele of the H locus. Homozygous animals (H/H) die before birth.

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Hereditary Equine Regional Dermal Asthenia (HERDA) is caused by the presence of abnormal collagen in the skin. This results in skin detachment, severe lesions, ulcerations and wound healing problems.

The disease occurs in the Quarter Horse and related breeds. It is inherited autosomal recessively.

Synonym: Ehlers-Danlos syndrome, hyperelastosis cutis