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Centronuclear Myopathy (CNM Dog)

Centronuclear Myopathy (CNM) is a hereditary muscle disease in Labrador Retrievers. The disease leads to muscle degeneration, uneven gait and a lack of patellar reflex.

The inheritance is autosomal recessive.

Synonym: Labrador Retriever Myopathy (LRM), hereditary myopathy of labrador retrievers (HMLR).

 

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Cerebellar Abiotrophy (CA Horse)

Cerebellar Abiotrophy (CA) describes ataxia in horses due to progressive death of brain cells responsible for movement. Affected animals show balance, coordination, and movement disorders, which pose a high risk of injury to both animal and rider. Depending on the severity, the animals suffer greatly from this disease, which is why euthanasia is often considered.

The disease occurs in Arabians and related breeds and is inherited autosomal recessively.

 

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Cerebellar hypoplasia | Dandy-Walker-like Malformation (DWLM Dog)

Cerebellar hypoplasia (also known as "Dandy-Walker-like malformation" DWLM) is a genetically caused malformation of the cerebellum. This leads to disorders and failures of body functions that are controlled by the cerebellum, especially movements. Symptoms are ataxia, epileptic seizures and tremor.

The disease occurs in Eurasiers. The inheritance is autosomal recessive.

 

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Also in the Eurasier 'DWLM + 2 colours' package

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Champagne (Diltution factor Horse)

The Champagne mutation lightens the coat, mane and tail of the horse (dilution). Less colour pigments are produced and the base colour appears faded. Depending on the base colour of the horse, different champagne shades appear: Classic Champagne (black), Gold Champagne (chestnut), Amber Champagne (bay).

One copy of the gene is sufficient (Ch/n or Ch/Ch) to trigger the dilution of the coat colour. It can easily be confused with other dilution factors and occur in combination with those e.g. with cream dilution.

 

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Also in the Dilution package

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Collie eye anomaly (CEA Dog)

Collie eye anomaly (CEA) is a developmental disorder of the eye characterised by choroidal hypoplasia (underdevelopment) and can lead to blindness in severe cases.

The disease occurs in Collie, Border Collie, Australian Shepherd and Shetland Sheepdog. The inheritance is autosomal recessive.

 

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Cone-rod dystrophy 3 | crd-PRA (crd3-PRA wirehaired Dachshund)

Cone-rod dystrophy 3 (crd3) is an eye disease in which the cones and rods on the retina degenerate. Clinical symptoms usually appear in the first 3 weeks of life and lead to total blindness in early adulthood.

The disease occurs in the wirehaired Dachshund (Teckel). The inheritance is autosomal recessive.

Synonym: crd-PRA

 

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Cone-rod dystrophy 4 | cord1 (crd4-PRA Dachshund)

Cone-rod dystrophy 4 (crd4) is an eye disease in which the cones and rods on the retina degenerate. Clinical symptoms usually appear in the first 3 weeks of life and lead to total blindness in early adulthood.

The disease occurs in the longhaired Dachshund (Teckel). The inheritance is autosomal recessive.

Synonym: cord1-PRA, crd4-PRA

 

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Also in the Hereditary diseases Dachshund 1 package

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Congenital Myotonia (CM Horse)

Congenital myotonia (CM) is caused by a malformed channel protein in skeletal muscle cells and results in impaired movement due to muscle rigidity.

The disease occurs in the New Forest Pony and is inherited in autosomal recessivly.

 

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Cream (Dilution factor Horse)

The Cream mutation lightens the coat, mane and tail of the horse (dilution) by reducing the amount of pigment produced in the skin cells and hair.

The Cream mutation is inherited in an incomplete autosomal dominant way, which means that animals with only one copy (Cr/n) show a less pronounced lightening than animals with two mutant alleles (Cr/Cr). If one copy of the mutation is present, less light/red pigment (pheomelanin) is deposited. If two copies are present, less of the light and dark/black pigment (eumelanin) is deposited. Horses with two copies appear almost completely white.

 

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Also in the Dilution package

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Cream | yellow | red (Coat colour E-Locus Dog)

Only the pigment phaeomelanin is produced, the dog has a red/light colour. This colouration is caused by the e-allele of the extension locus.

 

See: Extension (Coat colour E-Locus Dog)

 

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