Progressive rod-cone degeneration (prcd-PRA Dog)
Progressive rod-cone degeneration (prcd-PRA) is caused by degeneration of the retinal photoreceptor cells and, in the course of the disease, the entire retina is destroyed. Affected animals go blind.
The hereditary disease is one of the three forms of PRA in the Golden Retriever, but also occurs in many other breeds. The inheritance is autosomal recessive.
Genetic Test: available in Shop
Symptoms
- Night blindness in the early stages
- Visual disorders
- Complete blindness
General Information
- Progressive rod-cone degeneration (prcd-PRA) is caused by a degeneration of the photoreceptor cells (rods & cones).
- First, the rods responsible for light-dark vision lose their normal function.
- Later, the cones necessary for daylight and colour vision are also destroyed.
- The disease is progressive.
- In the course of the disease, the retina is completely destroyed.
- prcd-PRA is one of three forms of PRA in the Golden Retriever, GR-PRA 1 and GR-PRA 2 also occur.
Breeds affected
Labrador Retriever, Golden Retriever, other Retrievers (NSDTR, Chesapeake Bay) and various other breeds (Australian Shepherd, Poodle etc.)
Test Information
This test detects a missense mutation (c.5G>A) of the PRCD gene.
Test in Shop
The test is carried out in a partner laboratory.
Also in the Labrador Retriever A package (DRC P1)
Genotyp und Laborbefund
Inheritance: autosomal recessive.
→ The hereditary disease only occurs if both alleles of the gene are affected by the mutation (prcd/prcd). Dogs that have only one allele with the causative mutation (N/prcd) are clinically healthy carriers.
Genotypes:
N/N = genetically normal
The dog has no predisposition for prcd-PRA and therefore cannot pass it on to its offspring.
N/prcd = a carrier
The dog is a clinically healthy carrier. The variation is passed on 50% to the offspring, which are also carriers.
prcd/prcd = affected
The variation is passed on 100% to the offspring. The offspring are carriers or affected.
Recommendations
- Carrier animals can be bred to normal animals (N/prcd x N/N). Before using the offspring in breeding, it should be tested whether they are normal or carriers.
- Mating two carrier animals (N/prcd x N/prcd) should be avoided because there is a 25% chance that the offspring will be affected.
- Affected animals (prcd/prcd) should be excluded from breeding.
Literature
Zangerl, B., Goldstein, O., Philp, AR., Lindauer, SJ., Pearce-Kelling, SE., Mullins, RF., Graphodatsky, AS., Ripoll, D., Felix, JS., Stone, EM., Acland, GM., Aguirre, GD.: Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. Genomics :, 2006. Pubmed reference: 16938425. DOI: 10.1016/j.ygeno.2006.07.007.
Miyadera, K., Acland, G.M., Aguirre, G.D.: Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies. Mamm Genome 23:40-61, 2012. Pubmed reference: 22065099. DOI: 10.1007/s00335-011-9361-3.
Further information is available at: Online Mendelian Inheritance in Animals.