Lexicon

Hereditary Nasal Parakeratosis (HNPK) is a differentiation disorder of the skin cells (keratinocytes) in the area of the dog's nose. Affected dogs show firm scabs on the upper nose leather and thus a risk of cracks and fissures on the nose.

The pre-damaged skin can be more easily infected by pathogens, which can lead to complications. The animals are otherwise healthy.
The disease occurs in the Labrador Retriever. The inheritance is autosomal recessive.

Genetic Test: available in Shop

Also in the Labrador Retriever A package (DRC P1)

Hoof Wall Separation Disease (HWSD) is characterized by a defect in the connective tissue of the hoof wall. Affected animals have hooves that can be brittle and crack easily. The mutation was originally identified in Connemara ponies but has not also been found in Tinkers, Cobs, American Miniature Horses, and German Riding Ponies. It has an autosomal recessive mode of inheritance.

Genetic Test: available in Shop

In hydrocephalus, cerebrospinal fluid accumulation in the brain leads to enlarged skull and death of the foal. The disease occurs in Friesian horses and is inherited autosomal recessively.

Hyperkalemic Periodic Paralysis (HYPP) is caused by a malformed channel protein in skeletal muscle cells and results in temporary paralysis due to malfunctioning signal transmission from the brain to the muscles/organs.

The disease occurs in the Quarter Horse and related breeds. The inheritance is incomplete autosomal dominant.

In Hyperuricosuria and Hyperuricaemia (HUU), dogs excrete uric acid instead of allantoin in their urine. This causes increased formation of urinary stones, which can lead to problems.

The disease occurs in many breeds. It is inherited autosomal recessively.

Synonym: Urolithiasis

Genetic Test: available in Shop (in Labrador Retriever B package)

Iberian horses are among the oldest and most well-known breeds in Europe, originating from the Iberian Peninsula. These horses are renowned for their exceptional resilience, strength, and agility. They are further distinguished by their muscular build, noble head, and pronounced elegance. Due to their intelligent nature, versatility, and suitability for classical riding, Iberian horses are valued worldwide. They also appear in many modern horse breeds and have significantly influenced the development of numerous contemporary breeds.

Ichthyosis (PNPLA1-related) is a cornification disorder of the skin. This leads to defects in the development of the outer layer of the epidermis. Affected animals show increased scaling (desquamation) and detachment of the outer skin layer.

The hereditary disease occurs in the Golden Retriever. The inheritance is autosomal recessive.

Synonym: ICT-A

Genetic Test: available in Shop

Also in the Golden Retriever A package (DRC P2)

→ Coat pattern with negative effects on skin, coat, teeth and eyes

Junctional Epidermolysis Bullosa (JEB) is a skin disease that causes skin lesions and blistering due to a lack of connection between the individual skin layers. There may also be problems with their footpads.

The disease occurs in the German Shorthair Pointer. It is inherited in an autosomal recessively way.

Genetic Test: available in Shop

Juvenile myoclonic epilepsy (JME) is a form of epilepsy with sudden, electroshock-like muscle twitches and seizures. These often occur during the initial sleep phase or can also be triggered by sudden bright light. Most dogs have daily seizures.

The disease occurs in the Rhodesian Ridgeback. The inheritance is autosomal recessive.

Synonym: generalized myoclonic epilepsy

Genetic Test: available in Shop