Skip to main content

Lexicon

Narcolepsy (canarc1 Dachshund)

With narcolepsy (canarc-1), dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the dachshund. The inheritance is autosomal recessive.

Read more »

Narcolepsy (canarc1 Doberman)

With narcolepsy (canarc-1) dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the Doberman. The inheritance is autosomal recessive.

Read more »

Narcolepsy (canarc1 Labrador)

With narcolepsy (canarc-1) dogs suffer cataplectic episodes, a sudden onset of temporary flaccid paralysis of individual muscle groups or the entire skeletal musculature. Triggers are excitatory events or fright. Affected dogs also show unusual fatigue during the day.

This genetic variant of the disease occurs in the Labrador Retriever. The inheritance is autosomal recessive.

Read more »

Neuronal ceroid lipofuscinosis 1 (NCL1 Dachshund)

Neuronal ceroid lipofuscinosis 1 (NCL1) is a metabolism-induced neurodegenerative disease in Dachshunds caused by an alteration of a single base pair in exon 8 of the TPP1 gene. In this disease, a waste product of cell metabolism (ceroid lipofuscin, CL), is stored in the cells and is not metabolised further. CL accumulates in the nerve cells of the retina and brain. Affected animals therefore show symptoms such as visual disorders, balance disorders and later completely disoriented behaviour and physical degeneration.

The inheritance is autosomal recessive.

Read more »

Neuronal ceroid lipofuscinosis 2 (NCL2 Dachshund)

Neuronal ceroid lipofuscinosis 2 (NCL2) is a metabolism-induced neurodegenerative disease caused by a deletion of a single base pair in exon 4 of the TPP1 gene. In this disease, the waste product of cell metabolism, ceroid lipofuscin, is stored in the cells and is not metabolised further. This accumulates in the nerve cells of the retina and brain. Affected animals therefore show symptoms such as visual disorders, balance disorders and later completely disoriented behaviour and physical degeneration.

The disease occurs in Dachshunds. The inheritance is autosomal recessive.

 

Read more »

Neuronal ceroid lipofuscinosis 5 (NCL5 Golden Retriever)

Neuronal ceroid lipofuscinosis 5 (NCL5) is a metabolism-induced neurodegenerative disease caused by a deletion of two base pairs in exon 4 of the CLN5 gene. In this disease, the waste product of cell metabolism, ceroid lipofuscin, is stored in the cells and is not metabolised further. This accumulates in the nerve cells of the retina and brain. Affected animals therefore show symptoms such as visual disorders, balance disorders and later completely disoriented behaviour and physical degeneration.

The disease occurs in Golden Retrievers. The inheritance is autosomal recessive.

Read more »

Oculoskeletal dysplasia 1 (OSD1 Dog)

Oculoskeletal dysplasia 1 (OSD1) is caused by a lack or deficiency of collagen in the cartilage and ocular collagen, resulting in malformations (dysplasia) of both the skeleton and the eyes. Affected dogs show dwarfism due to short legs, especially the front legs. Retinal detachments and cataracts in the eye occur, resulting in blindness.

The disease occurs in the Labrador Retriever. It is inherited in an autosomal recessive manner.

Synonym: Retinal dysplasia (RD)

Read more »

Osteogenesis Imperfecta (OI Dachshund)

With osteogenesis imperfecta (brittle bone disease - OI) a reduction and malformation in the synthesis of collagen occurs, which is a major component of bone. As a result, affected animals have brittle bones and teeth and unusually elastic joints.

The disease occurs in dachshunds and is caused by a mutation in the SERPINH1 gene. The inheritance is autosomal recessive.

Read more »

Pattern-1 (Coat colour pattern Horse)

The PATN1 gene modifies the Leopard complex and together they lead to a increased amount of white in the pattern of at least 60% of the body, mostly to a full Leopard spotting.

If there is a mutation in the PATN1 gene but no Leopard complex, the PATN1 gene has no effect on the coat colour and the horse is a carrier for the mutation without being spotted itself.

Read more »

Pearl (Dilution factor Horse)

The Pearl mutation lightens the coat, mane and tail colour of the horse. It is visually very similar to champagne dilution and is located on the same gene as the cream dilution factor. The Pearl mutation is mainly found in Quarter Horses, Paints and related breeds.

Read more »