Lexicon

Oculoskeletal dysplasia 1 (OSD1) is caused by a lack or deficiency of collagen in the cartilage and ocular collagen, resulting in malformations (dysplasia) of both the skeleton and the eyes. Affected dogs show dwarfism due to short legs, especially the front legs. Retinal detachments and cataracts in the eye occur, resulting in blindness.

The disease occurs in the Labrador Retriever. It is inherited in an autosomal recessive manner.

Synonym: Retinal dysplasia (RD)

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With osteogenesis imperfecta (brittle bone disease - OI) a reduction and malformation in the synthesis of collagen occurs, which is a major component of bone. As a result, affected animals have brittle bones and teeth and unusually elastic joints.

The disease occurs in dachshunds and is caused by a mutation in the SERPINH1 gene. The inheritance is autosomal recessive.

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